What kind of genes are HERVH and SATA?

Critical Reading Form – Bundo, et al. 2014

Purpose: In 1-2 sentences, what was the research question the authors were trying to answer and why?

Central Thesis: Using only 1 sentence, state the authors’ thesis. What hypothesis were they testing?

Key Claims: What are two statements given by the authors to support the thesis? (The claims are usually stated in the discussion or conclusions section of the paper and explain how the data support or refute their initial hypothesis, ie why it is important..

1.

2.

Evidence (ie. Experimental Results): What evidence does the author use to support each of the key claims you identified?

1.

2.

Figure Analysis: Examine Figure 1C and read the results section of the paper for these experimental data carefully. Answer questions 1-4 below.

1A. What is shown in the left panel?

B. Which group(s) showed a statistically significant difference in mean L1 copy number as compared with controls?

2A. What is shown in the right panel?

B. Which group(s) showed a statistically significant difference in mean L1 copy number as compared with controls?

3A. What kind of genes are HERVH and SATA?

B. Why did the authors normalize the L1 copy number by comparison to both HERVH and SATA?

  1. What conclusion did the authors assert based on this data?

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